Overcoming difficulties developing an HIV vaccine

The development of an HIV vaccine has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are exceedingly rare within the average human. Yet, despite their low frequency these B cell precursors can outcompete their B cell competitors under the right conditions. https://www.sciencedaily.com/releases/2017/12/171226154211.htm